201: Vitamin K (K1 and K2 as MK-4)

Dr. Garrett Smith

Tuesday, June 3rd, 2025

LYL #201 References/Links:

https://docs.google.com/document/d/1-7YUwkTG2Rrh8eygjmj7DVB-BrjzBEZklnxW4-h-RSQ/edit?tab=t.0#heading=h.58o96xp3d4af

Nutrition Detective Vitamin K (K1 and K2 as MK-4)

Vitamin K – Nutrition Detective: https://nutritiondetective.com/collections/shop/products/vitamin-k-k2-mk-4-plus-k1-60-capsules?variant=51812250321064 

Vitamin K Basics:

What is Vitamin K? Everything You Need to Know About Vitamin K1 and K2: https://www.drstevenlin.com/what-is-vitamin-k/

Vitamin K2 and the Calcium Paradox: How a Little-Known Vitamin Could Save Your Life: Rheaume-Bleue, Kate: 9780062320049: Amazon.com: Books: https://www.amazon.com/Vitamin-K2-Calcium-Paradox-Little-Known/dp/0062320041/ 

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The Role of Vitamin K Status in Cardiovascular Health: Evidence from Observational and Clinical Studies – PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC5585988/ 

Reference to past show: Love Your Liver Livestream #125: TOPICAL #MAGNESIUM, Learn All About It Here! #toxicbiletheory   https://www.youtube.com/watch?v=zNGGUHoAmm8

Growing Evidence of a Proven Mechanism Shows Vitamin K2 Can Impact Health Conditions Beyond Bone and Cardiovascular – PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC8483258/ 

Vitamin K Contribution to DNA Damage—Advantage or Disadvantage? A Human Health Response: https://www.mdpi.com/2072-6643/14/20/4219 

Vitamin K Deficiency – StatPearls – NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK536983/ 

9 Vitamin K2 Benefits That Will Improve Your Health: https://www.drstevenlin.com/vitamin-k2-benefits/ 

Episode 157 Diabetes missing

“vitamin” A Induces Vitamin K Deficiency:

See Detailed Video Here: https://youtu.be/6g64iIqvGfg 

Mechanism of the Effect of Retinoic Acid and Squalene on Vitamin K Deficiency in the Rat – The Journal of Nutrition: https://jn.nutrition.org/article/S0022-3166(23)14995-9/abstract

Vitamin A DEPLETES Vit K2, Vit A Causes Vit K Deficiency Diseases! #VitaminAToxicity #VitaminADetox https://www.youtube.com/watch?v=6g64iIqvGfg

Effect of Indigestible Oils on Vitamin K Deficiency in the Rat – The Journal of Nutrition: https://jn.nutrition.org/article/S0022-3166(23)14994-7/abstract 

MK-7 Inhibits P-glycoprotein and Causes vitamin D to Accumulate:

Inhibition of P-glycoprotein in Caco-2 cells: effects of herbal remedies frequently used by cancer patients – PubMed: https://pubmed.ncbi.nlm.nih.gov/18570158/ 

Studies Find Quercetin & Natto K2 INHIBIT P-Glycoprotein Thus Increasing Susceptibility To Ivermectin Toxicity: https://timtruth.substack.com/p/studies-find-nattokinase-and-quercetin 

ABCB1 (P-glycoprotein) regulates vitamin D absorption and contributes to its transintestinal efflux – PubMed: https://pubmed.ncbi.nlm.nih.gov/30222077/ 

Vitamin K and Toxic Leaky Bile aka Cholestasis:

The Role of Vitamin K in Cholestatic Liver Disease: https://www.mdpi.com/2072-6643/13/8/2515 

Episodes 53 & 71 The Basics of Toxic Bile Paradigm

missed 1:12:50

Primary Billiary Chriosis PBC

In 2002…

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Love Your Liver Livestream #105: “Viral” Hepatitis = TOXICITIES & DEFICIENCIES, 3 Testimonials https://www.youtube.com/watch?v=_AEgui7R_wA

Conclusions…

Association of mortality among trauma patients taking preinjury direct oral anticoagulants versus vitamin K antagonists – PubMed: https://pubmed.ncbi.nlm.nih.gov/31439398/ 

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Emergency use of intravenous phytonadione (vitamin K1) for treatment of severe bleeding in a child with chronic cholestasis – PubMed: https://pubmed.ncbi.nlm.nih.gov/21642829/

High Dose Versus Low Dose:

Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women – PubMed: https://pubmed.ncbi.nlm.nih.gov/23702931/

Maximal dose-response of vitamin-K2 (menaquinone-4) on undercarboxylated osteocalcin in women with osteoporosis – PubMed: https://pubmed.ncbi.nlm.nih.gov/30816822/ 

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MK-4 Improves Testosterone:

Menaquinone-4 enhances testosterone production in rats and testis-derived tumor cells – PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC3180407/ 

All-Cause Mortality (Risk of Death):

Vitamin K status, cardiovascular disease, and all-cause mortality: a participant-level meta-analysis of 3 US cohorts – ScienceDirect: https://www.sciencedirect.com/science/article/pii/S0002916522011248