https://www.youtube.com/watch?v=reXVZJayiLA
Tuesday, October 21st, 2025 10AM Tuscon, AZ
Dr. Garrett Smith
NutritionDetective.com
Testimonials: https://docs.google.com/document/d/1TPO2wgUi_HiaIadwMKs-mko-2D2QQHfEzP_dyn2x7pY
Links for today’s show:
https://docs.google.com/document/d/1Xu_1AtuzKEaTqXq75rDKW8v88Fkmuz78EYVN2eQYS4s/
Love Your Liver Livestream #221
Research/Reference Links
GENERAL CONTENTS OF BLACK SEED OIL:
Nigella sativa L. Phytochemistry and Pharmacological Activities: A Review (2019-2021) – PubMed: https://pubmed.ncbi.nlm.nih.gov/35053168/
SMELL/ODOR:
- Pungent and peppery → black pepper, oregano, or cumin seed
- Herbal and resinous → thyme, camphor, or turpentine-like essential oils
- Slightly smoky or burnt → tar-like, diesel, or burnt rubber
- Bitter base → earthy, slightly rancid, sesame, or nutty
INSECTICIDE:
Insecticidal Activity of Thymoquinone and Related Compounds Against Culex quinquefasciatus (Diptera: Culicidae) – PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC5788314/
Smells:
TOXICITY:
Nigella sativa (black seed) safety: an overview – PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC10373399/
missed 37:20
Acute and chronic toxicity of Nigella sativa fixed oil – ScienceDirect: https://www.sciencedirect.com/science/article/abs/pii/S0944711304700847?via%3Dihub
Thymoquinone-induced platelet apoptosis – PubMed: https://pubmed.ncbi.nlm.nih.gov/21688304/
missing
In vitro toxicological properties of thymoquinone – PubMed: https://pubmed.ncbi.nlm.nih.gov/19010375/
Acute and subacute toxicity profiles of thymoquinone-loaded nanostructured lipid carrier in BALB/c mice – PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC5108596/
Insights into the Protective Effects of Thymoquinone against Toxicities Induced by Chemotherapeutic Agents: https://www.mdpi.com/1420-3049/27/1/226
Rhabdomyolysis and acute kidney injury after consumption of black seed oil – PubMed: https://pubmed.ncbi.nlm.nih.gov/38844000/
The effect of route of administration in thymoquinone toxicity in male and female rats – PubMed: https://pubmed.ncbi.nlm.nih.gov/23440704/
Antiproliferative and antiapoptotic effect of thymoquinone on cancer cells in vitro – PubMed: https://pubmed.ncbi.nlm.nih.gov/29749248/
missing 49:20
INHIBITS DETOX:
Influence of thymoquinone on glycoprotein changes in experimental hyperglycemic rats
Thymoquinone chemosensitizes human colorectal cancer cells to imatinib via uptake/efflux genes modulation – PubMed: https://pubmed.ncbi.nlm.nih.gov/33783002/
Inhibition of cytochrome P450 enzymes by thymoquinone in human liver microsomes – PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC6035319/
Effects of Thymoquinone on the Pharmacokinetics and Pharmacodynamics of Glibenclamide in a Rat Model – PubMed: https://pubmed.ncbi.nlm.nih.gov/26434126/
ACCUMULATES:
Thymoquinone as a Potential Neuroprotector in Acute and Chronic Forms of Cerebral Pathology – PubMed: https://pubmed.ncbi.nlm.nih.gov/32093593/
CHEMOTHERAPY DRUG:
Anticancer potential of Thymoquinone from Nigella sativa L.: An in-silico and cytotoxicity study | PLOS One: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0323804
Black cumin seed essential oil, as a potent analgesic and antiinflammatory drug – PubMed: https://pubmed.ncbi.nlm.nih.gov/15103664/
Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism – PubMed: https://pubmed.ncbi.nlm.nih.gov/15375533/
Thymoquinone suppresses the proliferation of renal cell carcinoma cells via reactive oxygen species-induced apoptosis and reduces cell stemness – PubMed: https://pubmed.ncbi.nlm.nih.gov/31298468/
Nigella sativa L. Phytochemistry and Pharmacological Activities: A Review (2019-2021) – PubMed: https://pubmed.ncbi.nlm.nih.gov/35053168/
IMMOBILIZES SPERM:
Investigation of the effects of thymoquinone (TQ) and polyvinylpyrrolidone (PVP) on the motility, viability, and chromatin status of sperm in normozoospermic semen samples – PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC10849407/
ESTROGENIC, FUNCTIONALLY & LITERALLY:
A randomized placebo-controlled crossover trial with phytoestrogens in treatment of menopause in breast cancer patients – PubMed: https://pubmed.ncbi.nlm.nih.gov/12798527/
Effect of Nigella sativa seed extract on estradiol, FSH levels, and vaginal maturity index in menopausal women: A randomized controlled trial – PubMed: https://pubmed.ncbi.nlm.nih.gov/40352190/
The possible short-term of Nigella sativa – L in the management of adolescent polycystic ovarian syndrome: results of a randomized controlled trial | Journal of Ovarian Research | Full Text: https://ovarianresearch.biomedcentral.com/articles/10.1186/s13048-024-01460-x
Effect of Nigella sativa on reproductive system in experimental menopause rat model – PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC4884222/
Black seed oil supplement had positive effects on blood concentration and mRNA expression levels of estrogen and SHBG in premenopausal women with overweight and obesity: a crossover, double blind, placebo controlled randomized clinical trial – European Journal of Cancer: https://www.ejcancer.com/article/S0959-8049(22)01462-9/abstract
Black seed oil supplement had positive effects on blood concentration and mRNA expression levels of estrogen and SHBG in premenopausal women with overweight and obesity: a crossover, double blind, placebo controlled randomized clinical trial – European Journal of Cancer: https://www.ejcancer.com/article/S0959-8049(22)01462-9/abstract
Hormonal Contents of Two Types of Black Seed (Nigella sativa) Oil: Comparative Study: https://www.researchgate.net/publication/232808421_Hormonal_Contents_of_Two_Types_of_Black_Seed_Nigella_sativa_Oil_Comparative_Study#fullTextFileContent
