172: SEMAGLUTIDE & GLP-1 RAs, A Liver & Bile Disaster! Subscriber Q&A! – Remote Energy Wellness by: JOSEPH WILLIAM BAKER®

November 12th, 2024

11:44 AM CDT

Dr. Garrett Smith
Links for today’s show: https://docs.google.com/document/d/1mYnIVEzEvtrMuYEr8rmi1wxeUuVFgG0hxB7TA6Kip5A/edit?tab=t.0

https://www.youtube.com/watch?v=5NSmlfwGrFA

Where GLP-1s come from

The development of Byetta (exenatide) from the venom of the Gila monster as an anti-diabetic agent – PubMed

https://pubmed.ncbi.nlm.nih.gov/21194543

GLP-1 Lawsuits

semaglutide class action lawsuit – Brave Search

https://search.brave.com/search?q=semaglutide+class+action+lawsuit&source=web&summary=1&summary_og=2438540b73b5fbe1a10a86

GLP-1 & Bile Connections

glp-1 bile pubmed – Brave Search

https://search.brave.com/search?q=glp-1+bile+pubmed&source=desktop&summary=1&summary_og=a5592b203d6a1e172fd6b6

40:30

Bile Acids Trigger GLP-1 Release Predominantly by Accessing Basolaterally Located G Protein–Coupled Bile Acid Receptors – PMC

https://pmc.ncbi.nlm.nih.gov/articles/PMC4606749

Role of Bile Acids and GLP-1 in Mediating the Metabolic Improvements of Bariatric Surgery – PMC

https://pmc.ncbi.nlm.nih.gov/articles/PMC6409186

Postprandial Dyslipidemia, Hyperinsulinemia, and Impaired Gut Peptides/Bile Acids in Adolescents with Obesity – PMC

https://pmc.ncbi.nlm.nih.gov/articles/PMC7065844

Different Effects of Once-weekly and Once-daily Administered GLP-1RA Semaglutide and Liraglutide on Bile Acid Diarrhea – PubMed

https://pubmed.ncbi.nlm.nih.gov/37908253

Duration Paradox…the “Benefits”

Effect of semaglutide on fatty liver disease biomarkers in patients with diabetes and obesity – PubMed

https://pubmed.ncbi.nlm.nih.gov/36549643

Effect of semaglutide on liver enzymes and markers of inflammation in subjects with type 2 diabetes and/or obesity – PubMed

https://pubmed.ncbi.nlm.nih.gov/31246368

Liver Injury

DRUG-INDUCED AUTOIMMUNE-LIKE HEPATITIS AND CHOLELITHIASIS ASSOCIATED WITH DULAGLUTIDE AND SEMAGLUTIDE USE IN A YOUNG ADULT: A CASE REPORT AND REVIEW OF LITERATURE | Journal of Population Therapeutics and Clinical Pharmacology

https://www.jptcp.com/index.php/jptcp/article/view/3950

Severe liver injury caused by semaglutide injection

http://www.cadrj.com/EN/10.3760/cma.j.cn114015-20230118-00028

Official journal of the American College of Gastroenterology | ACG

https://journals.lww.com/ajg/fulltext/2023/10001/s3653_semaglutide_induced_hepatotoxicity__a_rare.3880.aspx

Progressive Cholestasis and Biliary Cirrhosis After Initiating Oral Semaglutide: Report From the Drug-Induced Liver Injury Network – PMC

https://pmc.ncbi.nlm.nih.gov/articles/PMC9794239

Diseases with GLP-1 RAs

Adverse Effects of GLP-1 Receptor Agonists – PMC

https://pmc.ncbi.nlm.nih.gov/articles/PMC5397288

Rhabdomyolysis Associated With Semaglutide Therapy: A Case Report – PMC

https://pmc.ncbi.nlm.nih.gov/articles/PMC10773591

Association of Bile Duct and Gallbladder Diseases With the Use of Incretin-Based Drugs in Patients With Type 2 Diabetes Mellitus – PubMed

https://pubmed.ncbi.nlm.nih.gov/27478902

Association of Glucagon-Like Peptide-1 Receptor Agonist Use With Risk of Gallbladder and Biliary Diseases: A Systematic Review and Meta-analysis of Randomized Clinical Trials – PMC

https://pmc.ncbi.nlm.nih.gov/articles/PMC8961394

Stomach Not Emptying

Gastrointestinal adverse events associated with semaglutide: A pharmacovigilance study based on FDA adverse event reporting system – PMC

https://pmc.ncbi.nlm.nih.gov/articles/PMC9631444

Influence of semaglutide use on the presence of residual gastric solids on gastric ultrasound: a prospective observational study in volunteers without obesity recently started on semaglutide – PubMed

https://pubmed.ncbi.nlm.nih.gov/37466909

Semaglutide, delayed gastric emptying, and intraoperative pulmonary aspiration: a case report – PubMed

https://pubmed.ncbi.nlm.nih.gov/36977934