https://www.youtube.com/watch?v=ppMJ61XRkaM

Tuesday, May 20th, 2025 10AM MST

Dr. Garrett Smith

https://NutritionDetective.com
Links for today’s show: https://docs.google.com/document/d/1KtnuzgBAl8q92Ij-sLsIj9vHgbPMzHpONylSU1i_hxA

LYL Livestream #199 References:

Definition of all-trans retinoic acid

Modulation of plasma all-trans retinoic acid concentrations by the consumption of carotenoid-rich vegetables – PubMed: https://pubmed.ncbi.nlm.nih.gov/18653315/

Retinoic Acid, all trans | CAS 302-79-4 | SCBT – Santa Cruz Biotechnology: https://www.scbt.com/p/retinoic-acid-all-trans-302-79-4

All-Trans Retinoic Acid – Chemocare: https://chemocare.com/druginfo/all-trans-retinoic-acid

Topical tretinoin therapy and all-cause mortality – PubMed: https://pubmed.ncbi.nlm.nih.gov/19153339/

Liver Damage and Exposure to Toxic Concentrations of Endogenous Retinoids in the Pathogenesis of COVID-19 Disease: Hypothesis – PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC8392079/

Proprietary Lipid Nanoparticle Ingredients

Tetanus vaccine may be laced with anti-fertility drug. International / developing countries – PubMed: https://pubmed.ncbi.nlm.nih.gov/12346214/

Lipid Nanoparticles─From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement | ACS Nano: https://pubs.acs.org/doi/10.1021/acsnano.1c04996#

Assessment of the proposed intellectual property waiver as a mechanism to address the COVID-19 vaccine scarcity problem – PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC8921581/

Johnson & Johnson COVID-19 Vaccine Authorized by U.S. FDA For Emergency Use: https://www.jnj.com/media-center/press-releases/johnson-johnson-covid-19-vaccine-authorized-by-u-s-fda-for-emergency-usefirst-single-shot-vaccine-in-fight-against-global-

pandemic

Instagram: https://www.instagram.com/p/CUEqFqGqxAk/

PolitiFact | A redacted ingredient of the Pfizer COVID-19 vaccine is just water: https://www.politifact.com/factchecks/2021/oct/01/instagram-posts/redacted-ingredient-pfizer-covid-19-vaccine-just-w/

Storage Temperatures

Why Moderna And Pfizer Vaccines Have Different Cold Storage Requirements : Shots – Health News : NPR: https://www.npr.org/sections/health-shots/2020/11/17/935563377/why-does-pfizers-covid-19-vaccine-need-to-be-kept-colder-than-antarctica

Sigma-Aldrich retinoic acid product information:

https://www.sigmaaldrich.com/content/dam/sigma-aldrich/docs/Sigma/Product_Information_Sheet/1/r2625pis.pdf

Effects of storage and handling conditions on concentrations of individual carotenoids, retinol, and tocopherol in plasma – PubMed: https://pubmed.ncbi.nlm.nih.gov/3338183/

Retinoic Acid As Vaccine Adjuvant

(retinoic acid[Title/Abstract]) AND (adjuvant[Title/Abstract]) – Search Results – PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=(retinoic%20acid%5BTitle%2FAbstract%5D)%20AND%20(adjuvant%5BTitle%2FAbstract%5D)&sort=&page=4

Retinoic Acid as a Vaccine Adjuvant Enhances CD8+ T Cell Response and Mucosal Protection from Viral Challenge | Journal of Virology: https://journals.asm.org/doi/10.1128/jvi.00781-11

Study Details | Aerosol Combination Therapy of All-trans Retinoic Acid and Isotretinoin as A Novel Treatment for Inducing Neutralizing Antibodies in COVID -19 Infected Patients Better Than Vaccine : An Innovative Treatment | ClinicalTrials.gov: https://clinicaltrials.gov/study/NCT04396067

COVID Vaccines as “Self-Adjuvanting”

The mRNA COVID19 announcement marks a new era of preservative free vaccines | by Benne Will | Medium: https://medium.com/@bennewill/the-mrna-pfizer-covid19-announcement-marks-a-new-era-of-cleaner-and-preservative-free-vaccines-d82bea123954

Self-adjuvanting mRNA… | Harvard Office of Technology Development: https://otd.harvard.edu/explore-innovation/technologies/self-adjuvanting-mrna-platform-technology/

RIG-I – Wikipedia: https://en.wikipedia.org/wiki/RIG-I

Poison/”Vitamin A” is an adjuvant (think vaccines) and adjuvants cause autoimmunity – Nutrition Detective – Research Forum – Dr. Garrett Smith’s Research Forum: https://nutritionrestored.com/blog-forum/topic/poison-vitamin-a-is-an-adjuvant-think-vaccines-and-adjuvants-cause-autoimmunity/

Lipid Nanoparticles

mRNA Vaccine Delivery Using Lipid Nanoparticles: Therapeutic Delivery: Vol 7, No 5: https://www.tandfonline.com/doi/10.4155/tde-2016-0006

Effect of mRNA-LNP components of two globally-marketed COVID-19 vaccines on efficacy and stability | npj Vaccines: https://www.nature.com/articles/s41541-023-00751-6

All-trans retinoic acid-loaded lipid nanoparticles as a transdermal drug delivery carrier: Pharmaceutical Development and Technology: Vol 19, No 2: https://www.tandfonline.com/doi/abs/10.3109/10837450.2013.763261

“The release rate and colon-specific release behavior of BUD could be easily modified by regulating the number of coated layers.”

https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-023-01889-0

Nanoencapsulated retinoic acid as a safe tolerogenic adjuvant for intranasal vaccination against cutaneous leishmaniasis – PubMed: https://pubmed.ncbi.nlm.nih.gov/31133469/

Cyclodextrin + Retinoic Acid

2‐Hydroxypropyl‐β‐cyclodextrin increases aqueous solubility and photostability of all‐trans‐retinoic acid – Lin – 2000 – Journal of Clinical Pharmacy and Therapeutics – Wiley Online Library: https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1365-2710.2000.00285.x

Cyclodextrin is in Johnson & Johnson
https://www.cas.org/sites/default/files/documents/covid-vaccine-ingredients-us.pdf

mixxed 1:04 – 1:06

RA & Myocarditis

All-trans Retinoic Acid–Induced Isolated Myocarditis: A Case Report and Review of the Literature – PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC8299770/

A case of ATRA-induced isolated myocarditis in the absence of circulating malignant cells: demonstration of the t(15;17) translocation in the inflammatory infiltrate by in situ hybridisation – PubMed: https://pubmed.ncbi.nlm.nih.gov/20060166/

A rare case of perimyocarditis induced by all-trans retinoic acid administration during induction treatment of acute promyelocytic leukemia – PubMed: https://pubmed.ncbi.nlm.nih.gov/31750445/

Two cases of isolated symptomatic myocarditis induced by all-trans retinoic acid (ATRA) – PubMed: https://pubmed.ncbi.nlm.nih.gov/17619879/

New Study: Myocarditis Still Present in 80% of Cases at 6 Months: https://anthonycolpo.substack.com/p/new-study-myocarditis-still-present

Myocarditis Cases Reported After mRNA-Based COVID-19 Vaccination in the US From December 2020 to August 2021 | Vaccination | JAMA | JAMA Network: https://jamanetwork.com/journals/jama/fullarticle/2788346

ACE2 Connection

COVID-19: angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection – PubMed: https://pubmed.ncbi.nlm.nih.gov/33389262/

Upregulation of angiotensin-converting enzyme 2 by all-trans retinoic acid in spontaneously hypertensive rats – PubMed: https://pubmed.ncbi.nlm.nih.gov/15477383/

Association of all-trans retinoic acid treatment with the renin-angiotensin aldosterone system expression in glomerulosclerosis rats – PubMed: https://pubmed.ncbi.nlm.nih.gov/23144044/

Spike Protein & Retinoic Acid

Retinoic Acid Binding Protein – an overview | ScienceDirect Topics: https://www.sciencedirect.com/topics/medicine-and-dentistry/retinoic-acid-binding-protein

A Retinol Derivative Inhibits SARS-CoV-2 Infection by Interrupting Spike-Mediated Cellular Entry – PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC9426596/

Toxins | Special Issue : Toxin-Antibody Interactions: https://www.mdpi.com/journal/toxins/special_issues/toxin-antibody

Monoclonal Antibodies and Toxins—A Perspective on Function and Isotype – PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC3398419/

Vitamin A and Retinoic Acid in the Regulation of B-Cell Development and Antibody Production – PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC3789244

missed

Prevnar-13 vaccine failure in a mouse model for vitamin A deficiency – PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC5654488/

Antibody treatment of toxin poisoning–recent advances – PubMed: https://pubmed.ncbi.nlm.nih.gov/8057395/

missed 1:28:20